Anti-aging： diet is more reliable than medicine

　　Recently, in a new study published in the journal Cell Metabolism, the research team from the University of Sydney found that diet has a greater impact on aging and metabolic health than the three well-known anti-aging "magic drugs" metformin, rapamycin and resveratrol.

　　Previous studies have confirmed that reducing calorie intake is considered as the oldest known intervention to prolong life without malnutrition. In this era of overnutrition, the effectiveness of this strategy is more obvious. However, there is a very complicated interaction between drugs acting on nutrient sensing pathway and diet, and drugs can also target the same biochemical pathway as nutrients. Therefore, people always try to find a drug to improve metabolic health and delay aging without changing their eating habits. But Professor Stephen Simpson, the author of the research communication and academic director of the Charles Perkins Center of the University of Sydney, said: "In fact, diet is a good medicine. Our preclinical research shows that diet is more effective than drugs in controlling diseases such as diabetes, stroke and heart disease. "

　　In this new study, the researchers designed a complex mouse study involving 40 different treatments, each with different protein, fat and carbohydrate balance, calories and drug content. The purpose of this study is to detect the effects of three anti-aging drugs, metformin, rapamycin and resveratrol, on the liver, because the liver is the key organ to regulate metabolism. The results show that dietary energy and macronutrients have much greater influence on protein abundance than drugs, and protein abundance is an important factor affecting aging.

　　According to this, Simpson said that people all know what they eat will affect their health, but this study shows that food can greatly affect many processes in our cells. "This gives us an in-depth understanding of the impact of diet on health and aging. Since humans and mice have basically the same nutrient sensing pathways, I can say that compared with taking these three drugs, improving metabolic health by changing diet will gain greater benefits. "

　　(Han Yi)