China news agency, Beijing, September 29 (Reporter Li Yanan) National Medical Products Administration, China, announced on the 29th that as of May 2019, 69 applications for registration of drugs for treating rare diseases had been included in the priority review procedure in order to encourage the research and development of drugs for treating rare diseases. In the next step, we will continue to speed up the review and approval of drugs for the treatment of rare diseases and improve the supply guarantee level of drugs for rare diseases.

　　Data map: The doctor is taking medicine for the patient. China News Service reporter Yang Huafeng photo

　　The World Health Organization defines rare diseases as 0.65&permil of the total population; To 1 & permit; At present, there are about 6000 to 8000 kinds of rare diseases recognized internationally. According to incomplete statistics, there are more than 20 million patients with rare diseases in China.

　　National Medical Products Administration pointed out that in order to encourage the research and development of drugs for the treatment of rare diseases, the Opinions on Solving the Backlog of Drug Registration Applications was revised and implemented in December 2017, giving priority to the review and approval of drug registration applications in 18 situations, including drugs for the treatment of rare diseases. As of May 2019, National Medical Products Administration has included 69 applications for registration of drugs for the treatment of rare diseases in the priority review process, greatly accelerating the process of product development and listing.

　　In order to speed up the listing of overseas new drugs urgently needed for clinical use in China, National Medical Products Administration, together with relevant departments, jointly issued the Announcement on Relevant Matters Concerning the Review and Approval of Overseas New Drugs Needed for Clinical Use, which established a special channel for the review and approval of overseas new drugs urgently needed for clinical use, and concluded the treatment of rare drugs included in the special channel within three months.

　　According to the news from National Medical Products Administration, two lists of overseas new drugs urgently needed in clinic have been released, including 37 drugs for treating rare diseases. Up to now, there are selepag tablets for the treatment of idiopathic pulmonary hypertension, Elosulfatase-&alpha for the treatment of mucopolysaccharide storage disease; , Fengomode Hydrochloride Capsules for the treatment of multiple sclerosis, Eloizumab for the treatment of hypercholesterolemia, Icazumab for the treatment of paroxysmal nocturnal hemoglobinuria, Terfluramide tablets for the treatment of multiple sclerosis, Nosinasone Sodium Injection for the treatment of spinal muscular atrophy and Edaravone Injection for the treatment of amyotrophic lateral sclerosis were approved for import through this special channel. (End)

　　Beijing, May 9 (Reporter Zhang Ni) Recently, the nine-valent cervical cancer vaccine (HPV vaccine) was approved for listing in China, bringing good news to many women. HPV vaccine is the first vaccine in the world to include cancer as an indication. However, for many domestic people, this vaccine is still new, and the popularity of related knowledge is still limited.

　　How to vaccinate? How to choose the vaccine type that suits you? What preparations need to be made before vaccination? A few days ago, the reporter from Zhongxin. com interviewed Zhao Yun, deputy chief physician of gynecology department of Peking University People’s Hospital, on a series of issues of public concern.

　　— — What is the relationship between HPV virus and cervical cancer?

　　HPV is the abbreviation of the English name of "human papillomavirus". There are many members in the HPV family, and a few of them are closely related to malignant tumors, so they are called high-risk HPV. From the statistics of large population samples, 99% of cervical cancer is caused by infection with this kind of virus.

　　The main route of transmission of HPV virus is through sexual contact, and mucosal contact can also be transmitted.

　　When there is no sexual exposure, the probability of this virus infection is almost zero, but the probability of HPV infection in women who have sex is very high. About 70% to 80% of women may have been infected with this virus, especially when they are sexually active (usually before the age of 30), which is the peak of infection.

　　However, many infections are transient infections. With the increase of age, these viruses will be cleared away, and only a small number (10-15%) are in a state of persistent infection, which is the high-risk group of cervical precancerous lesions and cervical cancer.

　　— — What is the difference between bivalent, tetravalent and nonavalent vaccines?

　　At present, there are three kinds of HPV vaccines listed in the world: bivalent, tetravalent and nonavalent.

　　A bivalent vaccine can prevent infections caused by HPV16 and HPV18 viruses. International research data show that more than 70% of cervical cancer is caused by these two viruses.

　　The tetravalent vaccine can prevent the infection of HPV6, 11, 16 and 18 viruses. Although HPV6 and HPV11 are not high-risk HPV viruses of cervical cancer, they can cause condyloma of lower genital tract.

　　Nine-valent vaccine is aimed at nine subtypes of HPV6, 11, 16, 18, 31, 33, 45, 52 and 58. Studies show that nine-valent vaccine can prevent 90% of cervical cancer.

　　It should be pointed out that HPV vaccine can not prevent cervical cancer 100%, even after vaccination, cervical cancer screening should be carried out regularly.

　　— — What is the difference between the three vaccination ages?

　　In terms of vaccination age, the approved vaccination age in China is: bivalent vaccine is suitable for women aged 9-25, tetravalent vaccine is suitable for women aged 20-45, and ninevalent vaccine is suitable for women aged 16-26.

　　The division of age groups is determined based on the results of clinical experiments of different age groups in China. HPV vaccine is a preventive vaccine. At present, no results show that it has the effect of preventing diseases for people who have been infected with HPV virus contained in the vaccine. Therefore, population vaccination before sexual exposure has the best health economic effect.

　　In the position paper updated by WHO in May 2017, it is suggested that women aged 9-14 who have not had sex should be the main target population, and women over the age of 15 should be the secondary target population.

　　— — Is the applicable age of nine-valent vaccine in Hong Kong 9-45 years old?

　　The instructions for the nine-valent vaccine in Hong Kong are applicable to 9-45 years old. However, there is no clinical data on the effectiveness of using HPV nine-valent vaccine in people over 26 years old.

　　Hong Kong’s approval of the application for the elderly is mainly based on the effectiveness of the tetravalent vaccine for the elderly population. The nine-valent vaccine and the tetravalent vaccine are immune-bridged, so the application range is 9-45 years old.

　　— — Is it still useful to vaccinate married and fertile women?

　　Some married and fertile women have not been infected by the virus, or have not been infected by the HPV subtype contained in the vaccine. At this time, vaccination is also effective.

　　— — How many times does the vaccine need to be vaccinated?

　　The bivalent, tetravalent and nonavalent vaccines all need to be injected in three times and completed within six months.

　　Among them, bivalent vaccine is recommended to be inoculated in October, January and June, with a total of 3 doses. The second dose can be inoculated 1-2.5 months after the first dose, and the third dose can be completed 5-12 months after the first dose.

　　Four-valent and nine-valent vaccines are recommended to be vaccinated in October, February and June, with a total of three doses. The interval between the first dose and the second dose should be at least one month, and the interval between the second dose and the third dose should be at least three months. All three doses should be completed within one year.

　　— — Is it still necessary to vaccinate with nine valence after vaccination with four valence?

　　At present, there is not enough evidence to prove that it will be more beneficial to vaccinate another series after completing one series of vaccines.

　　From the clinician’s point of view, women who have been vaccinated with one of bivalent, tetravalent and nonavalent vaccines and completed all injections can prevent more than 70% of cervical cancer. Another HPV vaccine injection is not recommended.

　　The instructions for the nine-valent vaccine mentioned that after the third dose of tetravalent HPV vaccine was inoculated, the nine-valent vaccine was injected at least 12 months apart.

　　— — How long is the vaccine valid?

　　Bivalent and tetravalent vaccines have been on the market for more than ten years. At present, the research data show that the antibody level of the vaccinated population is still at a high level, and there is no evidence that it is necessary to strengthen vaccination.

　　The nine-valent vaccine was launched in 2014. Studies on people aged 9-15 and 16-26 showed that serum antibodies remained positive in the fifth year after vaccination. At present, there is no evidence of the need for intensive vaccination.

　　— — What tests should I do before vaccination?

　　No special examination is needed before vaccination. However, in my personal opinion, people who have been sexually exposed and have never been screened for cervical cancer before should be screened. The purpose of screening is to know whether they have cervical lesions.

　　— — Which groups are not suitable for vaccination?

　　People who are allergic to the active ingredients used in the vaccine or any dressing adjuvant should be prohibited from using it. People who have had hypersensitivity after injecting HPV vaccine should not be vaccinated again.

　　In addition, women who are pregnant and pregnant are not recommended to be vaccinated now. Although a large number of practices that have been put on the market have proved that there is no data showing that the vaccine will affect the growth and development of embryos, pregnancy preparation and pregnancy are special periods, so it is not recommended for such people to be vaccinated immediately.

　　— — What are the side effects of the vaccine?

　　At present, the safety of the vaccine is still very good. Vaccination of this kind of vaccine is the same as other vaccines. The common systemic adverse reactions are mainly headache, fever, nausea and dizziness, and the local adverse reactions are mainly pain, swelling, erythema and itching.

　　— — Can men be vaccinated?

　　At present, all vaccines approved in China are used by women to prevent cervical cancer.

　　In foreign countries, tetravalent vaccines approved by some countries can be used for male vaccination. Male vaccination can also prevent precancerous lesions of some reproductive organs, condyloma and so on.

　　In addition, male vaccination is beneficial to the emergence of group immune effect, which reduces the overall infection rate of HPV virus in the population.

　　— — What are the precautions for preventing cervical cancer?

　　To prevent cervical cancer, in addition to vaccination, regular screening should be conducted, especially for women who have had sexual exposure.

　　For healthy people under the age of 30, it is suggested that only cell screening should be carried out. If the screening result is negative, it can be checked again after 3 years. For healthy people over 30 years old, it is recommended to carry out cell screening and HPV virus examination. If the results are double negative, they can be examined again after 5 years.

　　Early sexual exposure, many sexual partners, active sexual behavior and unclean sexual behavior are all high risk factors for cervical cancer, so condoms are recommended for safe sex. In addition, developing a healthy lifestyle is also beneficial to the prevention of diseases.

On September 25th, official website, the Ministry of Agriculture and Rural Affairs, published the Reply to the Proposal No.5074 of the Second Session of the 13th National People’s Congress (hereinafter referred to as the Reply), which responded to the proposal of Xia Wu Zhuo Ma, a representative of the National People’s Congress, to enact a law prohibiting cruelty to animals. The "Reply" said that it is difficult to effectively crack down on cruelty to animals and other behaviors that are generally opposed by the public because of the lack of relevant legislative provisions. It is indeed necessary to improve legislation.

Legislation to prohibit cruelty to animals is still a relatively frontier topic in China’s current legislative work and has not been included in the recent legislative plan. But this does not mean that there are no relevant laws and regulations in China.

China’s animal husbandry law stipulates specific issues such as feeding, environment, setting, epidemic prevention, quarantine and transportation of livestock and poultry breeding, and clearly puts forward that "developing high-quality, efficient, ecological and safe animal husbandry"; The Law on the Protection of Wild Animals also states that "the state implements the principle of giving priority to the protection of wild animals, standardizing their utilization and strictly supervising them, encourages scientific research on wild animals, cultivates citizens’ awareness of protecting wild animals and promotes the harmonious development between man and nature". In the controversial field of animal experiments, China also has a special Regulation on the Management of Experimental Animals to ensure that the management of experimental animals follows unified planning and reasonable division of labor, and is transferred to the second edition.

Continued from the first edition is conducive to promoting the scientific research and application of experimental animals.

In 2010, the Ministry of Housing and Urban-Rural Development issued the Opinions on Further Strengthening the Management of Zoos, requiring zoos to make clear regulations on animal feed quality, cage conditions, heatstroke prevention and cold protection facilities, medical treatment, and the disposal of dead animals’ carcasses, and at the same time requiring no animal performances to avoid animals being disturbed and stimulated.

In practice, there are cases in which the cruelty to animals has a serious social impact, and legal responsibility is also investigated according to the relevant laws of our country. In 2002, Liu, a student from Tsinghua University, threw a bear with sulfuric acid at the Beijing Zoo, which aroused strong social repercussions. In April 2003, the People’s Court of Xicheng District, Beijing first sentenced Liu to intentional damage to property and was exempted from criminal punishment.

For some time, in order to attract the attention of netizens, there are often videos of cruelty to animals in live webcasts, and even a secret industrial chain of online customization and selling of such videos has been formed, which has had an extremely bad impact on society. According to the provisions of China’s cyber security law prohibiting "spreading violent, obscene and pornographic information", the relevant video producers can be investigated for legal responsibility according to law.

To sum up, although we don’t have a law prohibiting cruelty to animals or an animal welfare law, the law will not sit idly by and ignore cruelty to animals, which is a basic requirement of a society ruled by law.

Of course, the legislative suggestions of NPC deputies reflect that with the progress of society and the development of civilization, a clear, systematic and perfect law prohibiting cruelty to animals meets the people’s new requirements and expectations for the rule of law and social fairness and justice. The response of the Ministry of Agriculture and Rural Affairs released a clear signal-the state supports legislation prohibiting cruelty to animals, and the construction of the rule of law will keep pace with the development of social civilization.

We believe that legislation prohibiting cruelty to animals, which promotes human civilization, will soon become a reality.

　　[Report from the press conference of the State Council Office] 　

　　Guangming Daily, Beijing, July 22nd, by Guangming Daily reporter Yuan Yufei

　　On July 22nd, the State Council held a press conference on the traceability of Covid-19. Xu Nanping, Vice Minister of Science and Technology, Ceng Yixin, Deputy Director of the National Health and Wellness Commission, Wang Chen, Vice President of China Academy of Engineering, Dean of Peking Union Medical College and Director of the National Respiratory Medicine Center, Liang Wannian, Chinese leader of the China-World Health Organization joint research group on Covid-19 traceability, Yuan Zhiming, director of Wuhan National Biosafety Laboratory of Chinese Academy of Sciences and researcher of Wuhan Institute of Virology, and other authoritative experts actively responded to the hot issues of the traceability of the new coronavirus concerned by Chinese and foreign media.

　　On July 21, at a testing point in Xuanwu District, Nanjing, medical staff were conducting nucleic acid testing and sampling for the citizens. Xinhua News Agency reporter Ji Chunpeng photo

　　Q: Is the report on global traceability in Covid-19 released by the World Health Organization on March 30th authoritative?

　　Ceng Yixin:The problem of virus traceability is a complex scientific problem. Since the outbreak of the epidemic, every responsible country and every responsible scientist is eager to find out the source of Covid-19. This is of great significance to prevent similar epidemics from happening again.

　　On March 30th this year, the World Health Organization officially released the joint research report "Global Traceability Research in Covid-19: Part of China" convened by WHO, and the global traceability research made a good start.

　　Governments, scientists and the media all over the world are very concerned about this report. Since its release a few months ago, more and more scientific evidence shows that this report is valuable, authoritative and can stand the test of science and history. The conclusion of the report is scientific, and the process of production always adheres to scientific principles.

　　This traceability research report is the China part of the global traceability research. The expert group draws the following conclusions: Coronavirus, which is closely related to Covid-19, has the highest homology with Covid-19 in terms of sequence, but these viruses are still not enough to prove that they are the direct ancestors of Covid-19, and there is still a certain gap. Combined with the research results of clinical epidemiology, animal and environmental detection, the joint expert group finally determined several possibilities for the virus to appear: the first one is "possible to relatively possible", and zoonosis directly overflows, that is, it directly overflows from animal hosts to people. The second is "more likely to be very likely", which is introduced through an intermediate host. Generally speaking, the natural host of the virus is an animal, and then it transits to people through the intermediate host. The third is "possibility", which is introduced through the cold chain. In some sporadic epidemics in various places last year, it was found that cold chain transmission may introduce viruses. The last one is the introduction of "extremely unlikely" in the laboratory.

　　In the next stage, the traceability work should be carried out under the overall coordination of WHO, and on the basis of the first stage of research, excellent experts from many countries should be organized to carry out in-depth work, scientists should be the mainstay, exchanges and cooperation should be strengthened, and the traceability work in Covid-19 should be carried out on a scientific track.

　　Q: Is Covid-19 naturally produced or caused by human factors?

　　Ceng Yixin:I really want to talk about my views on the second phase of the virus traceability plan released by WHO on July 15th. To tell you the truth, I was very surprised. Because in this plan, the hypothesis that "China violated laboratory regulations and caused virus leakage" is one of the research focuses. From this point, I can feel the disrespect for common sense and arrogant attitude towards science revealed in this plan. It is impossible for us to accept such a traceability plan.

　　What is the purpose of traceability? It is to find out the source of the virus and then take effective measures to prevent similar epidemics from happening again. Therefore, we must promote this work in accordance with scientific principles and rules. This is the attitude of the China Municipal Government.

　　So far, none of the staff and graduate students of Wuhan Institute of Virology has been infected with COVID-19. Wuhan Institute of Virology has not carried out research on the gain function of coronavirus, and there is no so-called artificial virus. So where did the virus leak due to violation of laboratory regulations come from? Therefore, this formulation violates both common sense and scientific laws. More importantly, the WHO expert group personally visited Wuhan Virus Institute, and reached the conclusion that the virus is extremely unlikely to be leaked from the laboratory. They are all very authoritative and experienced experts in various fields carefully selected by WHO. So we should respect their conclusions.

　　Yuan Zhiming:The Wuhan Institute of Virology has repeatedly responded to the rumors about the leakage of virus laboratories. Covid-19 originated from nature, which has become a general consensus in academic circles. I want to emphasize that before December 30, 2019, Wuhan Institute of Virology had not contacted, preserved or studied Covid-19. Wuhan Virus Research Institute has never designed, manufactured or leaked Covid-19.

　　Facing the sudden outbreak of COVID-19, Wuhan Institute of Virology quickly identified novel coronavirus with the advantages of platform, technology and talents accumulated for a long time, isolated the virus strain, determined the whole genome sequence, and submitted the whole genome sequence to the United Nations World Health Organization on January 12, 2020. These important research results have provided a foundation for the global antiviral drug screening and vaccine research, and also won time for the global fight against the epidemic.

　　Q: Is the original data of early communication in Wuhan public?

　　Yuan Zhiming:The structure and content of the database of Wuhan Institute of Virology are still in the process of continuous improvement. At present, the database is shared within Wuhan Institute of Virology. After analyzing and systematically sorting out some original data in the database, the staff will publish the research results in the form of papers, and display and retrieve them in the database in a visual way. After analyzing and sorting out the original data of scientific research, it will be published in the form of papers, and then the database will be made public. This is the practice of scientific and technological circles, and the Institute of Virology will strictly follow the rules of scientific and technological circles to display and share our scientific data.

　　Wuhan Institute of Virology has always insisted on the timely sharing of scientific research information, and we released the whole genome sequence to the World Health Organization in time. As early as February 3, 2020, Shi Zhengli’s research team published a research paper in Nature, proposing that Covid-19 came from nature. After we found that several drugs have antiviral activity at the cellular level, we published the research results in international magazines on February 4. At the same time, Wuhan Virus Research Institute also actively participated in the international video and audio conference held by the World Health Organization, and timely shared our research results in animal model establishment, antiviral drug screening, inactivated vaccine development in COVID-19, etc.

　　Q: What do you think about the possibility of virus spread caused by trade in cold chain products?

　　Wang Chen:The role of cold chain in the spread of infectious diseases is a new phenomenon. From Beijing Xinfadi epidemic situation and Qingdao epidemic situation, we can see such a close relationship, that is, the patients have been exposed to the cold chain, and no other possible virus sources have been found outside the cold chain.

　　In the detection of virus nucleic acid, cold chain goods nucleic acid detection is positive. Especially in the Qingdao epidemic, not only the virus nucleic acid positive was detected on the surface of cold chain items, but also the virus was isolated and cultured, which confirmed that there was a live virus on the surface of cold chain items. Combining these two points, the chain of evidence is gradually complete.

　　In the process of further virus traceability, we especially suggest that the cold chain should be regarded as a key traceability clue. At present, under the background of international trade, people and goods exchange frequently all over the world, and people in the cold chain environment — The spread of things has increased the complexity, which is particularly worthy of investigation and research.

　　Guangming Daily (July 23, 2021, 09 edition)

　China Internet TV is a new media video service of Internet TV under CCTV, which is operated by Future TV Co., Ltd., a holding subsidiary of CCTV. In March, 2010, it was the first company to obtain the license of Internet TV integration service and content service issued by the State Administration of Press, Publication, Radio, Film and Television. Future TV, as a specialized operator of CCTV’s Internet TV business, was registered in Tianjin in December 2011, with "China Internet TV" as the call sign, and launched Internet TV business all over the world. Relying on the strong resource advantages of CCTV and its own professional operation advantages, China Internet TV has achieved global coverage of 150 million users, and cooperated with more than 40 leading technology enterprises at home and abroad, such as Samsung, Hisense, Changhong, Xiaomi, Huawei, China Mobile, China Unicom and Telecom, leading the development trend of domestic Internet TV.More > > >

Today, Xiaobian picked a car in the medium-sized mpv and introduced it to everyone. It is. As for the outstanding performance of the car, please read it together.

Let’s take a look at the appearance of Chuanqi E8 new energy. The front of Chuanqi E8 new energy is cold and unforgettable. Coupled with simple headlights, the shape is very eye-catching. The car is equipped with LED daytime running lights, automatic opening and closing, adaptive far and near light, delayed closing and so on. Coming to the side of the car, the size of the car body is 4920MM*1900MM*1760MM. The car adopts dignified lines, which gives people a very solid feeling. With large-sized thick-walled tires, it looks full of movement. Looking back, Chuanqi E8 New Energy’s tail line is individual, and the taillights present a simple and generous design style, and the overall layout is impressive.

Coming into the car, Chuanqi E8 new energy interior design is relatively deep, and the overall appearance is very solid. The steering wheel of this car is very fashionable, made of leather, and the visual effect is good. Let’s take a look at the central control. The car is equipped with a touch-sensitive LCD central control screen, which makes the interior style impressive and looks personalized. Let Xiaobian introduce the dashboard and seats. The dashboard design is remarkable and the information reading is simple and clear. The car uses leather seats, equipped with auxiliary seat with memory electric adjustment, seat with memory electric adjustment, seat proportion down and other functions, and the overall comfort and wrapping are not bad.

The car is equipped with car networking, driving mode selection, remote control key, Bluetooth key, rear wiper, interior atmosphere light and other configurations, which fully ensures the convenience and comfort of the car experience.

To sum up: I wonder if you are excited about this car introduced today?

In the colorful entertainment circle, every artist is fighting for his dream and life. Some people became a hit with a masterpiece, while others were controversial because of several works with poor evaluation in succession. Recently, Bao Beier, a powerful actor, gave a sincere and close-to-life answer to the question of "the poor quality of his works" from netizens, which aroused a wide discussion on the Internet for a time.

Bao Beier’s attitude in the face of doubt is impressive. In an open interview, he calmly responded to the criticism from the outside world with a self-deprecating frank attitude: "Yes, there is no other drama for me, so what to shoot. I am very satisfied to have the opportunity to film. Will I still be picky? " This remark not only made the reporters and audience on the scene laugh, but also quickly caused a heated discussion on the Internet.

In the highly competitive entertainment circle, the choice of actors is often limited. For Bao Beier, it is a kind of luck to get the script and have the opportunity to show his acting skills in front of the camera. He understands that in this industry, only a few actors can choose their own roles. Therefore, he chose to treat every performance opportunity with a peaceful attitude and cherish every performance. Bao Beier’s remarks not only reflect his true and humble personality, but also reflect the reality of the existence of entertainment actors. In this big dye vat, actors often have to face all kinds of temptations and challenges, and it is particularly precious to be able to keep their initial heart and stick to their beliefs and principles.

Of course, Bao Beier’s answer also inspired the netizens to think deeply. In the process of chasing box office and fame, how actors should grasp the quality of their works and how to balance the balance between business and art has become a topic worth pondering. After all, what the audience wants to see is those works that are rich in depth and interest, rather than the poor works that only attract attention and earn box office.

In fact, Bao Beier’s acting career is also full of twists and turns. He has also experienced the low point of his career, and some of his works have been questioned. But these experiences made him cherish every performance opportunity more and work harder to improve his acting skills and comprehensive quality. He knows very well that as an actor, only by constantly challenging himself and exceeding the limit can he gain a firm foothold in the entertainment industry and continue to grow and develop.

Looking forward to the future, we expect Bao Beier to keep this humble and diligent attitude, dare to challenge himself and bring more wonderful works to the audience. At the same time, we also hope that the whole entertainment circle can pay more attention to the quality and connotation of the works and offer more artistic masterpieces with depth and temperature to the audience. In this era of rapid consumption, the works that really touch the heart are the most precious.

As a senior blogger of entertainment film reviews, I strongly suggest that you must learn to use advanced productive forces and use AI in your daily work and life. No matter who you are, no matter how familiar you are with your business, don’t exclude AI. Smart people have used AI tools like Sohu Simple AI, but most people in the workplace only know how to work hard, and as a result, they suffer from information occlusion. People who can use AI and those who can’t, the work efficiency is really different! In fact, as long as you are willing to spend some time learning how to use it, simple operation can make your work efficiency several times and save a lot of time to do your own thing. For example, my commonly used AI tool-[Sohu Simple AI] is an all-round AI creative assistant, whose functions include AI painting, Wen Sheng Tu, Tu Sheng Tu, AI copywriting, AI avatar, AI material, AI design and so on. You can generate creative beautiful pictures, anime avatars, notes on planting grass, explosion titles, activity plans, etc. with one click. Sohu simple AI link (free, long press the copy link to make the browser experience, or click the link at the end of the text to experience): https://ai.sohu.com/pc/generate? trans=030001_pjj_0809

Editor in charge:

　　Tianjin Jinli Automobile Sales Co., Ltd.: is a company that sells Mercedes-Benz, BMW, Porsche, Land Rover, Audi, Bentley, Maserati, Toyota, Lexus, and other luxury car brands and high-end cars.

　　Car purchase quadruple guarantee

　　The first guarantee: the original regular commodity car to ensure that the new car is not an accident repair car.

　　The second guarantee: to ensure the quality, the manufacturer has done professional testing for each car before leaving the factory.

　　The third layer of protection: to ensure that all vehicles sold can be registered normally across the country, according to the National V emission standards.

　　The fourth guarantee: the procedures on the day of purchase are taken away with the car (close the ticket, commodity inspection, consistency certificate, invoice, electronic information QR code)

　　You should know

　　When it comes to the Land Rover Defender, many people first think of the hard off-road label, and the hard off-road vehicles are basically from the military. However, the life of the Land Rover Defender is different. After World War II, the British industry was in ruins, and it was indeed inappropriate to reproduce cars at the time. Influenced by the Mercedes-Benz G and Jeep Willis, the British who were always gentlemen also began to conceive of their own off-road vehicles. This car is not a by-product of the war but a derivative after the war.

　　Series I (1948 – 1958)

　　On April 30, 1948, at the Amsterdam Motor Show, the Series I came out, and at the same time the new car brand Land Rover was born. Many people in the UK love Land Rover or Land Rover Defender, and I think the most important reason is because there was only one model in the first 22 years of the Land Rover brand – the Series (later Defender).

　　At the beginning of the launch of the Series I model, there was only one 80 model available. The 80 we mentioned here refers to the wheelbase of the model, and the measurement unit is naturally inches. Power is also very monotonous. It is equipped with a 1.6L naturally aspirated gasoline engine with a maximum power of 51Ps, matched by a 4-speed manual transmission.

　　This kind of power is difficult to make people have the urge to go off-road, but the tough appearance is still a classic in today’s eyes. In 1949, the 80-inch wheelbase did not meet the needs of the British. The Series I model was launched in a 7-seat version, with no changes in power but leather interior.

　　After the space was satisfied, Land Rover introduced a 2.0L gasoline version in 1954, and the introduction of the higher-displacement model was motivated by the British House of Representatives removing the model from commercial vehicle status (commercial vehicles were limited to 30 mph in the UK at the time).

　　The 86-inch model replaced the 80 model, and the longer wheelbase 107 model came out in 1957 with a 2.0L diesel engine with a maximum power of 52Ps and a hard roof design with metal plates and bolts. The original wooden roof was forever a thing of the past.

　　Series II (1958 – 1971)

　　The Series I model was a huge success. Land Rover began to strike while the iron was hot and launched the Series II model. The biggest change in the appearance of this replacement is the waist line on the side, which runs from the front fender to the rear.

　　The models are divided into 88 and 109, and the 2.25L gasoline engine has been updated from the original 2.0L 51Ps to 72Ps. The transmission is still 4-speed manual.

　　The famous Land Rover Series began to export to the world, and the Series II A model became the main export model. Since it was an export model, Land Rover wanted to show the best to the world in all aspects. In 1967, the long-wheelbase version of the Series IIA added a 2.6-liter inline six-cylinder gasoline engine, of which 811 were sold to the United States and Canada.

　　By 1969, Series IIA sales reached their peak. From 1969 to 1970, Series IIA’s annual sales reached 60,000 units. In the same year, 2.0L diesel engines were also added to the Series IIA product line. Personally, I think diesel engines and hardcore off-road are the perfect match.

　　Series III (1971 – 1985)

　　The Series III is the biggest change in the Land Rover Series series, and in my opinion the most classic generation model. The biggest changes in the Series III and Series II are the shift of the headlights on the sides of the front face to the left and right and the 22-year-old metal front grille to plastic.

　　The biggest change in terms of power is the increase of the maximum power of the 3.5L V8 gasoline engine by 91Ps. The 2.25L diesel engine, 2.0L and 2.6L gasoline engine power parameters have not been upgraded.

　　Due to its outstanding off-road performance, the Series III became a British military vehicle, and some models exported to Australia and New Zealand were also used as military vehicles by local governments.

　　However, in the field of military vehicles, the reliability of Land Rover does have problems, and it is often complained by the Australian soldiers at that time. Until the discontinuation of Series III in 1985, the most legendary model of Land Rover entered a new chapter. At this time, the Defender is about to be born.

　　Guard Forever

　　Our subtitle is Defender Forever, forever is not a model. At present, the Defender model has been discontinued. Since the name Defender was determined, the appearance of the Defender model has not undergone major changes.

　　Why was the Series model renamed the Defender? We have to jump back in time to 1970, the birth of the Range Rover, when consumers often had difficulty distinguishing between the Series and the Range Rover. When it came to 1989, the problem became more and more serious after the model was introduced.

　　The name at the time was like this – that is, there would be Range Rover (Range Rover), Discovery (Discovery) and Land Rover 90/110/127 for sale in the Land Rover store, which caused more and more confusion to consumers. As a result, the Land Rover model, which had shared the name with the brand for decades, urgently needed a name of its own.

　　After careful consideration by Land Rover executives – the name Defender was born. Adhering to the pedigree of hard-core off-road vehicles, the appearance of the Defender model is still boxy, and the interior is also minimalist and the configuration is pitiful.

　　However, in today’s passenger car industry, it is very rare for the front and rear suspension to use an integrated bridge structure, and the guard has been quietly adhering to this design, the main purpose is to maximize the strength of the body, so that it can adapt to various harsh use environments.

　　The four-wheel drive structure of the guard does not have electronic limited slip and wheel-to-wheel differential lock, and its four-wheel drive still looks a bit old. Although the appearance and four-wheel drive structure have not changed for nearly 20 years, there are still differences in engines from different periods. Imagine if it were not for environmental protection policies, the power parameters might not have changed much.

　　Defender started with a 2.5-liter inline-four-cylinder diesel turbocharged engine. In 1998 Land Rover replaced the 300TDi with a 2.5-liter inline-five-cylinder turbocharged diesel codenamed Td5, and in 2007 a 2.4-liter inline-four-cylinder turbocharged diesel from Ford replaced the Td5.

　　In addition to diesel power, the 1998 50th Anniversary Defender used a 4.0-liter V8 petrol engine from the Range Rover and was paired with a 4-speed automatic transmission from the ZF.

　　The increasingly stringent environmental protection policies made it difficult for diesel engines to survive. On the eve of the shutdown of the Defender, Land Rover equipped it with an engine from Ford’s ZSD-422 that met the Euro 5 emission standards. Its maximum power on the Defender was adjusted to 122Ps and a maximum torque of 360 Nm. The torque performance was in line with the positioning of a hardcore off-road, and it was paired with a 6-speed manual transmission. However, the acceleration time of 100 kilometers is 14.3 seconds, and the speed of 135km/h is still obediently to conquer the mud danger.

　　summary

　　The probability of the Land Rover Defender appearing on the streets of the UK is as great as we see the Jetta Santana in China. The relatively low price, strong off-road performance and huge modification space make this car a tool car for the British people. But with the discontinuation of the Defender model and the emergence of a new generation of Defender render graph, the price of the domestic Defender has not dropped but risen. The price of up to 70W will keep many people out. The reason for this is not the expensive price, but the price is difficult to be proportional to the vehicle. People who really choose it in China must have rigid needs or have full feelings. By Zhang Dongxu

　　Tianjin Jinli Automotive Sales Co., Ltd.

　　All series of models in the store are sold in stock, and regional sales are not restricted!, all taken by real cars in the store. The latest price can be called: WeChat, the content photos are all taken by the entities in the store, and the physical merchants should beware of being deceived.

　　Government procurement designated units, honest enterprises, new car sales are complete in color, and can be sold all over the country to enjoy the national joint guarantee treatment. Do business with sincerity and treat people with trust! A handshake, forever friends!

　　Business address: Jinli Automobile, No. 116, 1st Floor, No. 236 Jinbin Avenue, Tianjin Port Free Trade Zone

　　Tel: 13260231234 13302063750 Manager Zhang WeChat

　　If you buy a car from other places, you can take the high-speed rail to get off the bus in Tanggu, and you can pick it up by plane.

　　Disclaimer: The above car purchase discount information is provided by the comprehensive dealer on this website. Due to market factors, the price fluctuates greatly, and it is only for car purchase reference. Its authenticity, accuracy and legality are the responsibility of the dealer. This website does not provide any guarantee and does not assume any legal responsibility.

Lynk & Co 08 is a new mid-to-large luxury SUV launched by the Lynk & Co brand jointly established by Geely Automobile and Volvo Cars, which uses a gasoline-electric hybrid powertrain.

This model is equipped with Volvo’s Drive-E series 2.0TD T5 engine with a maximum power of 187kW and a maximum torque of 350Nm. At the same time, it is also equipped with a set of Siemens high-efficiency motors with a maximum power of 65kW and a maximum torque of 240Nm. This hybrid system has a combined maximum power of 250kW and a combined maximum torque of 510Nm.

In terms of transmission, the Lynk & Co 08 is equipped with a 7-speed dual-clutch transmission and BorgWarner Timely 4WD system. The car’s 0-100km/h acceleration time is only 6.8 seconds, and the combined fuel consumption is 2.2 liters per 100km.

In addition, Lynk & Co 08 is also equipped with an energy recovery system that converts some of the kinetic energy into electricity during braking and coasting and stores it in the battery, thus further improving fuel economy.

Overall, the Lynk & Co 08, as a gasoline-electric hybrid SUV, offers both power performance and fuel economy, making it a model worth considering when purchasing a car.